Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities Describes the genes implicated in autistic spectrum disorders and their function Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

Can a company be cool, socially responsible ... and still make money? Welcome to the looptail. This is the extraordinary true story of Bruce Poon Tip and how, with nothing more than two credit cards and a burning desire to create an authentic, sustainable travel experience like nothing the world had ever seen, he created G Adventures, the world's most successful adventure travel company. G Adventures operates in more than 100 countries, on all seven continents, serves more than 100,000 customers every year - and is now a significant player in Australia. In this unique first-person account, Poon Tip reveals his unusual management secrets that allowed him to keep growing his company, his employees fully engaged and energised, and his customers extremely happy. This is a singularly stunning story of why community, culture and karma matter in business, and how one man's desire to do the right thing and generate profits can be blended into a win–win for all involved. In this special Australian edition, Bruce Poon Tip writes about the unique experiences and lessons learned which have fuelled the growth of his Australian business, and also about how Australia really could be better at presenting itself to the world's travellers. www.gadventures.com.au

There is a legal maxim, "fictio cedit veritati" that means fictions yields to truth. "First in Time" includes the transcription of conversation between two longtime "pacifists" which clearly evidences a "Living Truth" beyond the presumption of any fictitious record or narrative created specifically to gain access to One's genuine nature via trespass, as well as a highly deductive and learned exposition by the Author as to the lawful scope of such enlightened testimony. It is a must read for anyone with "eyes to see" the absurdity and confusion of a world completely devoid of Truth.

The journal discusses articles on gene action, regulation, and transmission in both plant and animal species, including the genetic aspects of botany, cytogenetics and evolution, zoology, and molecular and developmental biology.

Language, Literacy, and Learning: Theory and Application is an academic textbook for graduate students studying speech-language pathology and a useful clinical resource for practicing speech-language pathologists (SLPs). This text explores how aspects of orthography and word learning relate to speech production and reading comprehension in children and adults with typical development or language learning differences. It is essential that SLPs assess and treat language and literacy skills in their clients. This text is uniquely designed to help SLPs build their own skillsets in facilitating the development of the literacy skills that are crucial for navigating educational, vocational, and recreational experiences. This evidence-based resource includes clinical examples to support chapter information, with a focus on the science of reading and writing, typical and exceptional reading and writing development, and assessments and interventions for individuals with reading and writing differences. The author uses a student-friendly writing style that promotes learning at various levels of thinking: remembering, understanding, applying, analyzing, evaluating, and creating. Key Features: * An overview of current and influential theoretical models, the research supporting these models, and the evidence challenging each model * Detailed table of current published and standardized reading assessments for children, adolescents, and adults * Chapters featuring interviews with family members or teachers of individuals who have had experience with reading differences * Highlights of the accessibility and cultural implications of the presented information * Supplementary activities for instructors to conduct in class to support learning Language, Literacy, and Learning: Theory and Application is also a useful resource for special education teachers who work with students experiencing reading differences.

BMX bikes are iconic. There’s something about them that appeals to kids, adults and cyclists. And, of course, BMX is now an Olympic sport. Rad Rides is the most in-depth exploration of the world of BMX bikes through their riders and the culture that surrounds them. The introduction explains and contextualizes the birth of BMX culture and where it is now, while the main body features bikes ranging from those that are well-worn through years of riding to beautiful, sculptural works of art – gleaming, built-but-never-ridden keepsakes. The featured bikes are organized decade by decade and are BMXs drawn from the best collections in the world. There are also in-depth details of specifications and interviews with some of the collectors, many of whom have had their bikes exclusively shot for the book. This is the indispensable companion for anyone who loves the BMX.

These are the best bikes to be found anywhere right now, giving every kind of cyclist an overview of what is out there. Whether a BMXtreme or mountain bike enthusiast, a keen tourer or racer, a city commuter or courier, or simply fascinated with the constantly advancing mechanics and engineering of folding and other innovative bike designs, this book has something for you. The bikes on display come from across Europe, East and South Asia and North America, not to mention examples from the southern hemisphere. The major bike manufacturers like Boardman, Giant and Fuji are of course featured, but also more maverick material from Biomega, Calfee and Daymak. 100 Best Bikes is the essential resource for anyone wanting to know about the best in design and engineering for every kind of bike.