Kinetics of Enzyme-Modifier Interactions
Title | Kinetics of Enzyme-Modifier Interactions PDF eBook |
Author | Antonio Baici |
Publisher | Springer |
Total Pages | 503 |
Release | 2015-06-24 |
Genre | Science |
ISBN | 3709114020 |
The kinetic mechanisms by which enzymes interact with inhibitors and activators, collectively called modifiers, are scrutinized and ranked taxonomically into autonomous species in a way similar to that used in the biological classification of plants and animals. The systematization of the mechanisms is based on two fundamental characters: the allosteric linkage between substrate and modifier and the factor by which a modifier affects the catalytic constant of the enzyme. Combinations of the physically significant states of these two characters in an ancestor-descendant-like fashion reveal the existence of seventeen modes of interaction that cover the needs of total, partial and fine-tuning modulation of enzyme activity. These interactions comprise five linear and five hyperbolic inhibition mechanisms, five nonessential activation mechanisms and two hybrid species that manifest either hyperbolic inhibition or nonessential activation characteristics depending on substrate concentration. Five essential activation mechanisms, which are taxonomically independent of the mentioned basic species, complete the inventory of enzyme modifiers. Often masked under conventional umbrella terms or treated as anomalous cases, all seventeen basic inhibition and nonessential activation mechanisms are represented in the biochemical and pharmacological literature of this and the past century, either in the form of rapid or slow-onset reversible interactions, or as irreversible modification processes. The full potential of enzyme inhibitors and activators can only be appreciated after elucidating the details of their kinetic mechanisms of action exploring the entire range of physiologically significant reactant concentrations. This book highlights the wide spectrum of allosteric enzyme modification in physiological occurrences as well as in pharmacological and biotechnological applications that embrace simple and multiple enzyme-modifier interactions. The reader is guided in the journey through this still partly uncharted territory with the aid of mechanistically-oriented criteria aimed at showing the logical way towards the identification of a particular mechanism.
Principles of Enzyme Kinetics
Title | Principles of Enzyme Kinetics PDF eBook |
Author | Athel Cornish-Bowden |
Publisher | Elsevier |
Total Pages | 221 |
Release | 2014-05-20 |
Genre | Science |
ISBN | 1483164675 |
Principles of Enzyme Kinetics discusses the principles of enzyme kinetics at an intermediate level. It is primarily written for first-year research students in enzyme kinetics. The book is composed of 10 chapters. Chapter 1 provides the basic principles of enzyme kinetics with a brief discussion of dimensional analysis. Subsequent chapters cover topics on the essential characteristics of steady-state kinetics, temperature dependence, methods for deriving steady-state rate equations, and control of enzyme activity. Integrated rate equations, and introductions to the study of fast reactions and the statistical aspects of enzyme kinetics are provided as well. Chemists and biochemists will find the book invaluable.
Enzyme Kinetics
Title | Enzyme Kinetics PDF eBook |
Author | Arthur R. Schulz |
Publisher | Cambridge University Press |
Total Pages | 264 |
Release | 1994-11-25 |
Genre | Medical |
ISBN | 9780521449502 |
This text covers the field of steady-state kinetics from basic principles to the control of the multi-enzyme systems which constitute metabolic pathways. Emphasis is placed on the interpretation of the kinetic behaviour of enzyme-catalyzed reactions in terms of mechanisms. Algorithms are developed which can be implemented in computer programs for the derivation of equations. The treatment of steady-state enzyme kinetics is extended to allosteric enzymes and subunit interactions in polymeric enzymes. Principles are presented which provide for mathematical analysis of the control of multi-enzyme systems. Problems are included at the end of each chapter and their solutions are found at the end of the book. This book will be a useful text for advanced undergraduates and graduate students taking courses in enzyme chemistry and enzyme kinetics.
Enzyme Kinetics
Title | Enzyme Kinetics PDF eBook |
Author | Hans Bisswanger |
Publisher | John Wiley & Sons |
Total Pages | 320 |
Release | 2008-06-25 |
Genre | Science |
ISBN | 3527622039 |
This new, expanded and updated edition of the user-friendly and comprehensive treatise on enzyme kinetics expertly balances theory and practice. This is an indispensable aid for advanced students and professionals working with enzymes, whether biochemists, biotechnologists, chemical biologists, pharmacologists or bioengineers in academia, industry and clinical research.
Enzyme Kinetics: Catalysis and Control
Title | Enzyme Kinetics: Catalysis and Control PDF eBook |
Author | Daniel L. Purich |
Publisher | Elsevier |
Total Pages | 915 |
Release | 2010-06-16 |
Genre | Science |
ISBN | 0123809258 |
Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions
Kinetics of Enzyme Mechanisms
Title | Kinetics of Enzyme Mechanisms PDF eBook |
Author | Jeffrey Tze-Fei Wong |
Publisher | |
Total Pages | 304 |
Release | 1975 |
Genre | Science |
ISBN |
Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays
Title | Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays PDF eBook |
Author | H. Gerhard Vogel |
Publisher | Springer |
Total Pages | 0 |
Release | 2013-02-27 |
Genre | Medical |
ISBN | 9783642252396 |
-A landmark in the continuously changing world of drugs -Essential reading for scientists and managers in the pharmaceutical industry involved in drug finding, drug development and decision making in the development process -Of use for government institutions and committees working on official guidelines for drug evaluation worldwide