Kernel Methods in Computational Biology
Title | Kernel Methods in Computational Biology PDF eBook |
Author | Bernhard Schölkopf |
Publisher | MIT Press |
Total Pages | 428 |
Release | 2004 |
Genre | Computers |
ISBN | 9780262195096 |
A detailed overview of current research in kernel methods and their application to computational biology.
Kernel Methods in Bioengineering, Signal and Image Processing
Title | Kernel Methods in Bioengineering, Signal and Image Processing PDF eBook |
Author | Gustavo Camps-Valls |
Publisher | IGI Global |
Total Pages | 431 |
Release | 2007-01-01 |
Genre | Technology & Engineering |
ISBN | 1599040425 |
"This book presents an extensive introduction to the field of kernel methods and real world applications. The book is organized in four parts: the first is an introductory chapter providing a framework of kernel methods; the others address Bioegineering, Signal Processing and Communications and Image Processing"--Provided by publisher.
Kernel Methods for Pattern Analysis
Title | Kernel Methods for Pattern Analysis PDF eBook |
Author | John Shawe-Taylor |
Publisher | Cambridge University Press |
Total Pages | 520 |
Release | 2004-06-28 |
Genre | Computers |
ISBN | 9780521813976 |
Publisher Description
Learning with Kernels
Title | Learning with Kernels PDF eBook |
Author | Bernhard Scholkopf |
Publisher | MIT Press |
Total Pages | 645 |
Release | 2018-06-05 |
Genre | Computers |
ISBN | 0262536579 |
A comprehensive introduction to Support Vector Machines and related kernel methods. In the 1990s, a new type of learning algorithm was developed, based on results from statistical learning theory: the Support Vector Machine (SVM). This gave rise to a new class of theoretically elegant learning machines that use a central concept of SVMs—-kernels—for a number of learning tasks. Kernel machines provide a modular framework that can be adapted to different tasks and domains by the choice of the kernel function and the base algorithm. They are replacing neural networks in a variety of fields, including engineering, information retrieval, and bioinformatics. Learning with Kernels provides an introduction to SVMs and related kernel methods. Although the book begins with the basics, it also includes the latest research. It provides all of the concepts necessary to enable a reader equipped with some basic mathematical knowledge to enter the world of machine learning using theoretically well-founded yet easy-to-use kernel algorithms and to understand and apply the powerful algorithms that have been developed over the last few years.
Kernel Methods in Chemo- and Bioinformatics
Title | Kernel Methods in Chemo- and Bioinformatics PDF eBook |
Author | Holger Fröhlich |
Publisher | Logos Verlag Berlin |
Total Pages | 0 |
Release | 2006 |
Genre | Bioinformatics |
ISBN | 9783832514396 |
This thesis is devoted to the finding of possible solutions for some machine learning related problems in modern chemo- and bioinformatics by means of so-called kernel methods. They are a special family of learning algorithms that have attracted a growing interest during the last years due to their good theoretical foundation and many successful practical applications in various disciplines. At the core of all kernel methods is the usage of a kernel function, which can be thought of as a special similarity measure between arbitrary objects. At the beginning of this thesis fundamentals and principles of kernel machines are reviewed. Afterwards a novel algorithm for model selection for Support Vector Machines (SVMs) in classification and regression is proposed, which is based on ideas from global optimization theory. It does not make any assumptions about special properties of the kernel function, like differentiability, and is highly efficient. Experimental comparisons to existing algorithms yield good results. After this we turn our point of interest to applications of kernel methods in chemo- and bioinformatics: For the ADME in silico prediction problem in modern drug discovery descriptor and graph-based representations of molecules are investigated. A descriptor selection algorithm is proposed, which can improve the statistical stability of an existing method. Furthermore, a novel class of specialized kernel functions is introduced that allows the comparison of a pair of molecules on a graph-based level. Various combinations of graph and descriptor-based representations are investigated, which on one hand allow the incorporation of expert domain knowledge and on the other hand the integration of different notions of molecular similarity in one SVM model. Furthermore, a reduced graph representation for molecular structures is proposed, in which certain structural elements are condensed in one node of the graph. Our experiments indicate that with our method improvements of the prediction performance compared to state-of-the-art modelling approaches can be achieved. At the same time our method is computationally rather cheap, unified and highly flexible. Another question, that is examined in the content of this thesis, is, which features of the membrane potentiel (MP) determine the generation of action potentials (APs) in cortical neurons in vivo. SVMs are trained to predict the occurrence of an AP before its onset based on several extracted features of the MP. A specialized feature selection algorithm is then used to select the most important features simultaneously in several in vivo recordings. In conclusion we find that the occurrence of an AP not only depends on the value of the MP shortly before AP onset, but also on the MP rate of change, the increase of the membrane potential several ms before AP onset, and the long range mean MP. Our findings systematically extend investigations by other researchers and are partially also confirmed by their results. As a last application of kernel methods in this thesis, we deal with the problem of clustering genes with regard to their function based on their Gene Ontology (GO) annotation. For this purpose specialized kernel functions are developed, which measure the similarity between gene products with respect to the structure of the GO graph. Using several clustering algorithms, like kernel k-means, spectral clustering and average linkage, we can detect meaningful clusters with our method. Applications to other ontologies or taxonomies in principle are possible.
Handbook of Statistical Bioinformatics
Title | Handbook of Statistical Bioinformatics PDF eBook |
Author | Henry Horng Lu |
Publisher | |
Total Pages | 640 |
Release | 2011-05-19 |
Genre | |
ISBN | 9783642163463 |
Encyclopedia of Bioinformatics and Computational Biology
Title | Encyclopedia of Bioinformatics and Computational Biology PDF eBook |
Author | |
Publisher | Elsevier |
Total Pages | 3421 |
Release | 2018-08-21 |
Genre | Medical |
ISBN | 0128114320 |
Encyclopedia of Bioinformatics and Computational Biology: ABC of Bioinformatics, Three Volume Set combines elements of computer science, information technology, mathematics, statistics and biotechnology, providing the methodology and in silico solutions to mine biological data and processes. The book covers Theory, Topics and Applications, with a special focus on Integrative –omics and Systems Biology. The theoretical, methodological underpinnings of BCB, including phylogeny are covered, as are more current areas of focus, such as translational bioinformatics, cheminformatics, and environmental informatics. Finally, Applications provide guidance for commonly asked questions. This major reference work spans basic and cutting-edge methodologies authored by leaders in the field, providing an invaluable resource for students, scientists, professionals in research institutes, and a broad swath of researchers in biotechnology and the biomedical and pharmaceutical industries. Brings together information from computer science, information technology, mathematics, statistics and biotechnology Written and reviewed by leading experts in the field, providing a unique and authoritative resource Focuses on the main theoretical and methodological concepts before expanding on specific topics and applications Includes interactive images, multimedia tools and crosslinking to further resources and databases