High-Throughput Screening in Drug Discovery
Title | High-Throughput Screening in Drug Discovery PDF eBook |
Author | Jörg Hüser |
Publisher | John Wiley & Sons |
Total Pages | 362 |
Release | 2006-12-13 |
Genre | Science |
ISBN | 3527609369 |
Backed by leading authorities, this is a professional guide to successful compound screening in pharmaceutical research and chemical biology, including the chemoinformatic tools needed for correct data evaluation. Chapter authors from leading pharmaceutical companies as well as from Harvard University discuss such factors as chemical genetics, binding, cell-based and biochemical assays, the efficient use of compound libraries and data mining using cell-based assay results. For both academics and professionals in the pharma and biotech industries working on small molecule screening.
A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery
Title | A Practical Guide to Assay Development and High-Throughput Screening in Drug Discovery PDF eBook |
Author | Taosheng Chen |
Publisher | CRC Press |
Total Pages | 291 |
Release | 2009-12-21 |
Genre | Medical |
ISBN | 1420070517 |
The development of suitable assays, the integration of appropriate technology, and the effective management of the essential infrastructure are all critical to the success of any high-throughput screening (HTS) endeavor. However, few scientists have the multidisciplinary experience needed to control all aspects of an HTS drug discovery project. A P
High Throughput Screening
Title | High Throughput Screening PDF eBook |
Author | William P. Janzen |
Publisher | Humana Press |
Total Pages | 265 |
Release | 2002-04-18 |
Genre | Medical |
ISBN | 9780896038899 |
In High Throughput Screening, leading scientists and researchers expert in molecular discovery explain the diverse technologies and key techniques used in HTS and demonstrate how they can be applied generically. Writing to create precisely the introductory guidebook they wish had been available when they started in HTS, these expert seasoned authors illuminate the HTS process with richly detailed tutorials on the biological techniques involved, the management of compound libraries, and the automation and engineering approaches needed. Extensive discussions provide readers with all those key elements of pharmacology, molecular biology, enzymology, and biochemistry that will ensure the identification of suitable targets and screens, and detail the technology necessary to mine millions of data points for meaningful knowledge.
High Throughput Screening Methods
Title | High Throughput Screening Methods PDF eBook |
Author | Joshua A. Bittker |
Publisher | Royal Society of Chemistry |
Total Pages | 416 |
Release | 2016-12-08 |
Genre | Medical |
ISBN | 1782624716 |
High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.
High Throughput Screening
Title | High Throughput Screening PDF eBook |
Author | John P. Devlin |
Publisher | CRC Press |
Total Pages | 704 |
Release | 1997-05-06 |
Genre | Science |
ISBN | 9780824700676 |
Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.
High-Throughput Screening for Drug Discovery
Title | High-Throughput Screening for Drug Discovery PDF eBook |
Author | Shailendra K. Saxena |
Publisher | BoD – Books on Demand |
Total Pages | 130 |
Release | 2022-05-25 |
Genre | Medical |
ISBN | 1839629479 |
The book focuses on various aspects and properties of high-throughput screening (HTS), which is of great importance in the development of novel drugs to treat communicable and non-communicable diseases. Chapters in this volume discuss HTS methodologies, resources, and technologies and highlight the significance of HTS in personalized and precision medicine.
High Throughput Screening
Title | High Throughput Screening PDF eBook |
Author | Mark Wigglesworth |
Publisher | |
Total Pages | 362 |
Release | 2020 |
Genre | Technology & Engineering |
ISBN | 9781536172539 |
"High Throughput Screening (HTS) is one of several hit identification approaches that are part of a developing and evolving toolbox for the discovery of pharmaceutical start points. HTS remains one of the most successful approaches, and therefore an important foundation of drug discovery. In High Throughput Screening: Methods, Techniques and Applications, leading industrial and academic experts in screening and drug discovery explain key technologies and methods while demonstrating how they can be applied to successful hit identification. Describing both traditional and emerging methods in detail, this book provides an overview of these methods to the reader that will serve both those new to the field and expert scientists alike. High Throughput Screening: Methods, Techniques and Applications provides readers with an outline of key elements in the areas of assay development, detailed descriptions of a range of both biochemical and cell-based screening methodologies and strategies, as well as highlighting important steps in data analysis. By describing the basic principles of methods commonly used in HTS, High Throughput Screening: Methods, Techniques and Applications provides an illuminating introduction to HTS, capturing established good practice within the field, thereby imparting both the industrial and academic researcher with the knowledge required to work effectively in both today's and the hit identification laboratories of the future"--