Gene and Cell Therapy

Gene and Cell Therapy
Title Gene and Cell Therapy PDF eBook
Author Nancy Smyth Templeton
Publisher CRC Press
Total Pages 894
Release 2003-12-17
Genre Science
ISBN 0824758609

Download Gene and Cell Therapy Book in PDF, Epub and Kindle

This reference is completely revised and expanded to reflect the most critical studies, controversies, and technologies impacting the medical field, including probing research on lentivirus, gutless adenovirus, bacterial and baculovirus vectors, retargeted viral vectors, in vivo electroporation, in vitro and in vivo gene detection systems, and all inducible gene expression systems. Scrutinizing every tool, technology, and issue impacting the future of gene and cell research, it is specifically written and organized for laymen, scholars, and specialists from varying backgrounds and disciplines to understand the current status of gene and cell therapy and anticipate future developments in the field.

A Handbook of Gene and Cell Therapy

A Handbook of Gene and Cell Therapy
Title A Handbook of Gene and Cell Therapy PDF eBook
Author Clévio Nóbrega
Publisher Springer Nature
Total Pages 195
Release 2020-06-27
Genre Medical
ISBN 3030413330

Download A Handbook of Gene and Cell Therapy Book in PDF, Epub and Kindle

This is a reference handbook for young researchers exploring gene and cell therapy. Gene therapy could be defined as a set of strategies modifying gene expression or correcting mutant/defective genes through the administration of DNA (or RNA) to cells, in order to treat disease. Important advances like the discovery of RNA interference, the completion of the Human Genome project or the development of induced pluripotent stem cells (iPSc) and the basics of gene therapy are covered. This is a great book for students, teachers, biomedical researchers delving into gene/cell therapy or researchers borrowing skills from this scientific field.

Gene and Cell Therapy: Biology and Applications

Gene and Cell Therapy: Biology and Applications
Title Gene and Cell Therapy: Biology and Applications PDF eBook
Author Giridhara R. Jayandharan
Publisher Springer
Total Pages 305
Release 2018-09-12
Genre Medical
ISBN 9811304815

Download Gene and Cell Therapy: Biology and Applications Book in PDF, Epub and Kindle

Recent advances in stem cell biology, nanotechnology and gene therapy have opened new avenues for therapeutics. The availability of molecular therapeutics that rely on the delivery of DNA, RNA or proteins, harnessing enhanced delivery with nanoparticles, and the regenerative potential of stem cells (adult, embryonic or induced pluripotent stem cells) has had a tremendous impact on translational medicine. The chapters in this book cover a range of strategies for molecular and cellular therapies for human disease, their advantages, and central challenges to their widespread application. Potential solutions to these issues are also discussed in detail. Further, the book addresses numerous advances in the field of molecular therapeutics that will be of interest to the general scientific community. Lastly, the book provides specific examples of disease conditions for which these strategies have been transferred to the clinic. As such, it will be extremely useful for all students, researchers and clinicians working in the field of translational medicine and molecular therapeutics.

Regulatory Aspects of Gene Therapy and Cell Therapy Products

Regulatory Aspects of Gene Therapy and Cell Therapy Products
Title Regulatory Aspects of Gene Therapy and Cell Therapy Products PDF eBook
Author Maria Cristina Galli
Publisher Springer Nature
Total Pages 243
Release 2023-08-01
Genre Science
ISBN 3031345673

Download Regulatory Aspects of Gene Therapy and Cell Therapy Products Book in PDF, Epub and Kindle

This book discusses the different regulatory pathways for Advanced Therapy Medicinal Products implemented by national agencies in North and South America, Europe and Asia and by international bodies in the effort of international harmonization. This book represents an update of the first edition, as it covers regulatory novelties and accumulated experience in the regions already addressed. In addition, this new edition offers a wider international perspective: new chapters are included covering Advanced Therapy Medicinal Products regulations in India, Malaysia, Spain and Thailand, the European Pharmacopoeia texts for gene therapy medicinal products as well as international harmonization programs. Each chapter, authored by experts from various regulatory bodies throughout the international community, walks the reader through the applications of nonclinical research to translational clinical research to licensure and therapeutic use of these innovative products. More specifically, each chapter offers insights into fundamental considerations that are essential for developers of Advanced Therapy Medicinal Products in the areas of product quality, pharmacology and toxicology, clinical trial design and HTA pathways, as well as pertinent ‘must-know’ guidelines and regulations. Regulatory Aspects of Gene Therapy and Cell Therapy Products: a Global Perspective is part of the American Society of Gene & Cell Therapy sub-series of the highly successful Advances in Experimental Medicine and Biology series. It is essential reading for graduate students, clinicians, and researchers interested in gene and cell therapy and the regulation of pharmaceuticals.

Cell and Gene Therapies

Cell and Gene Therapies
Title Cell and Gene Therapies PDF eBook
Author Miguel-Angel Perales
Publisher Springer
Total Pages 288
Release 2018-11-27
Genre Medical
ISBN 3319543687

Download Cell and Gene Therapies Book in PDF, Epub and Kindle

In this book, experts in the field express their well-reasoned opinions on a range of complex, clinically relevant issues across the full spectrum of cell and gene therapies with the aim of providing trainee and practicing hematologists, including hematopoietic transplant physicians, with information that is relevant to clinical practice and ongoing research. Each chapter focuses on a particular topic, and the concise text is supported by numerous working tables, algorithms, and figures. Whenever appropriate, guidance is provided regarding the availability of potentially high-impact clinical trials. The rapid evolution of cell and gene therapies is giving rise to numerous controversies that need to be carefully addressed. In meeting this challenge, this book will appeal to all residents, fellows, and faculty members responsible for the care of hematopoietic cell transplant patients. It will also offer a robust, engaging tool to aid vital activities in the daily work of every hematology and oncology trainee.

Gene and Cellular Immunotherapy for Cancer

Gene and Cellular Immunotherapy for Cancer
Title Gene and Cellular Immunotherapy for Cancer PDF eBook
Author Armin Ghobadi
Publisher Springer Nature
Total Pages 371
Release 2022-01-01
Genre Medical
ISBN 303087849X

Download Gene and Cellular Immunotherapy for Cancer Book in PDF, Epub and Kindle

Clinical and preclinical exploration of gene and cellular immunotherapy have seen rapid growth and interest with the development and approval of five Chimeric Antigen Receptor T-cell (CAR-T) products for lymphoma and myeloma and one Bispecific T-Cell Engager (BiTE) for acute lymphoblastic leukemia (ALL). These advances have dramatically improved the management of patients with relapsed refractory lymphoma, myeloma and leukemia. Gene and Cellular Immunotherapy for Cancer offers readers a comprehensive review of current cellular and gene-based immunotherapies. Divided into eighteen cohesive chapters, this book provides an in-depth and detailed look into cellular-based immunotherapies including CAR-T, TCR-T, TIL, Viral CTLs, NK cells in addition to T/NK cell engagers, focusing on their historical perspectives, biology, development and manufacturing, toxicities and more. Edited by two leading experts on gene and cellular immunotherapy, the book will feature chapters written by a diverse collection of recognized and up-and-coming experts and researchers in the field, providing oncologists, immunologists, researchers and clinical and basic science trainees with a bench to bedside view of the latest developments in the field.

Exploring Novel Clinical Trial Designs for Gene-Based Therapies

Exploring Novel Clinical Trial Designs for Gene-Based Therapies
Title Exploring Novel Clinical Trial Designs for Gene-Based Therapies PDF eBook
Author National Academies of Sciences, Engineering, and Medicine
Publisher National Academies Press
Total Pages 127
Release 2020-08-27
Genre Medical
ISBN 0309672988

Download Exploring Novel Clinical Trial Designs for Gene-Based Therapies Book in PDF, Epub and Kindle

Recognizing the potential design complexities and ethical issues associated with clinical trials for gene therapies, the Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine held a 1-day workshop in Washington, DC, on November 13, 2019. Speakers at the workshop discussed patient recruitment and selection for gene-based clinical trials, explored how the safety of new therapies is assessed, reviewed the challenges involving dose escalation, and spoke about ethical issues such as informed consent and the role of clinicians in recommending trials as options to their patients. The workshop also included discussions of topics related to gene therapies in the context of other available and potentially curative treatments, such as bone marrow transplantation for hemoglobinopathies. This publication summarizes the presentation and discussion of the workshop.