Stem Cells and the Future of Regenerative Medicine
Title | Stem Cells and the Future of Regenerative Medicine PDF eBook |
Author | Institute of Medicine |
Publisher | National Academies Press |
Total Pages | 112 |
Release | 2002-01-25 |
Genre | Science |
ISBN | 0309170427 |
Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Guidelines for Human Embryonic Stem Cell Research
Title | Guidelines for Human Embryonic Stem Cell Research PDF eBook |
Author | National Research Council |
Publisher | National Academies Press |
Total Pages | 224 |
Release | 2005-09-15 |
Genre | Medical |
ISBN | 0309096537 |
Since 1998, the volume of research being conducted using human embryonic stem (hES) cells has expanded primarily using private funds because of restrictions on the use of federal funds for such research. Given limited federal involvement, privately funded hES cell research has thus far been carried out under a patchwork of existing regulations, many of which were not designed with this research specifically in mind. In addition, hES cell research touches on many ethical, legal, scientific, and policy issues that are of concern to the public. This report provides guidelines for the conduct of hES cell research to address both ethical and scientific concerns. The guidelines are intended to enhance the integrity of privately funded hES cell research by encouraging responsible practices in the conduct of that research.
Human Embryonic Stem Cells
Title | Human Embryonic Stem Cells PDF eBook |
Author | Arlene Chiu |
Publisher | Springer Science & Business Media |
Total Pages | 455 |
Release | 2003-08-01 |
Genre | Science |
ISBN | 1592594239 |
A discussion of all the key issues in the use of human pluripotent stem cells for treating degenerative diseases or for replacing tissues lost from trauma. On the practical side, the topics range from the problems of deriving human embryonic stem cells and driving their differentiation along specific lineages, regulating their development into mature cells, and bringing stem cell therapy to clinical trials. Regulatory issues are addressed in discussions of the ethical debate surrounding the derivation of human embryonic stem cells and the current policies governing their use in the United States and abroad, including the rules and conditions regulating federal funding and questions of intellectual property.
Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research
Title | Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research PDF eBook |
Author | National Research Council |
Publisher | National Academies Press |
Total Pages | 112 |
Release | 2007-03-22 |
Genre | Medical |
ISBN | 0309179602 |
It is widely understood that stem cell treatments have the potential to revolutionize medicine. Because of this potential, in 2004 California voters approved Proposition 71 to set up a 10-year, $3 billion program to fund research on stem cells. Under the direction of the California Institute for Regenerative Medicine, this program will pay to build facilities for stem cell research and will fund doctors and scientists to carry out research with the ultimate goal of helping to develop therapies based on stem cells. For this research to move forward, however, will require a steady supply of stem cells, particularly human embryonic stem cells. Those stem cells are collected from developing human embryos created from eggs-or oocytes-harvested from the ovaries of female donors. Thus much of the promise of stem cells depends on women choosing to donate oocytes to the research effort. The oocyte donation process is not without risk, however. Donors are given doses of hormones to trigger the production of more eggs than would normally be produced, and this hormone treatment can have various side effects. Once the eggs have matured in the ovary, they must be retrieved via a surgical procedure that is typically performed under anesthesia, and both the surgery and the anesthesia carry their own risks. Furthermore, given the very personal nature of egg donation, the experience may carry psychological risks for some women as well. With this in mind, in 2006 the California Institute for Regenerative Medicine contracted with the National Academies to organize a workshop that would bring together experts from various areas to speak about the potential risks of oocyte donation and to summarize what is known and what needs to be known about this topic. The Committee on Assessing the Medical Risks of Human Oocyte Donation for Stem Cell Research was formed to plan the workshop, which was held in San Francisco on September 28, 2006. This report is a summary and synthesis of that workshop.
The Ethics of Embryonic Stem Cell Research
Title | The Ethics of Embryonic Stem Cell Research PDF eBook |
Author | Katrien Devolder |
Publisher | OUP Oxford |
Total Pages | 176 |
Release | 2015-01-22 |
Genre | Philosophy |
ISBN | 0191036226 |
Embryonic stem cell research holds unique promise for developing therapies for currently incurable diseases and conditions, and for important biomedical research. However, the process through which embryonic stem cells are obtained involves the destruction of early human embryos. Katrien Devolder focuses on the tension between the popular view that an embryo should never be deliberately harmed or destroyed, and the view that embryonic stem cell research, because of its enormous promise, must go forward. She provides an in-depth ethical analysis of the major philosophical and political attempts to resolve this tension. One such attempt involves the development of a middle ground position, which accepts only types or aspects of embryonic stem cell research deemed compatible with the view that the embryo has a significant moral status. An example is the position that it can be permissible to derive stem cells from embryos left over from in vitro fertilisation but not from embryos created for research. Others have advocated a technical solution. Several techniques have been proposed for deriving embryonic stem cells, or their functional equivalents, without harming embryos. An example is the induced pluripotent stem cell technique. Through highlighting inconsistencies in the arguments for these positions, Devolder argues that the central tension in the embryonic stem cell debate remains unresolved. This conclusion has important implications for the stem cell debate, as well as for policies inspired by this debate.
The Human Embryonic Stem Cell Debate
Title | The Human Embryonic Stem Cell Debate PDF eBook |
Author | Suzanne Holland |
Publisher | MIT Press |
Total Pages | 294 |
Release | 2001 |
Genre | Bioethics |
ISBN | 9780262582087 |
Discusses the ethical issues involved in the use of human embryonic stem cells in regenerative medicine.
Human Embryonic Stem Cells
Title | Human Embryonic Stem Cells PDF eBook |
Author | Ann A. Kiessling |
Publisher | Jones & Bartlett Learning |
Total Pages | 240 |
Release | 2003 |
Genre | Medical |
ISBN | 9780763723415 |
The emerging field of human embryonic stem cell biomedicine crosses many disciplinary boundaries-cell biology, reproductive biology, embryology, molecular biology, endocrinology, immunology, fetal med