Presenting a monumental achievement: 50 years of data cataloging the immediate, long-term, and hereditary effects of atomic radiation on the survivors of the Hiroshima and Nagasaki bombs. Authored by one of the key members of the Atomic Bomb Casualty Commission founded in 1947, this unique work documents the critical findings and conclusions of the longest ongoing medical study in history; it will surely become the foundation for all future investigations and standards regarding the bioeffects of ionizing radiation. "In my opinion, Dr. Schull has written a very interesting and accurate account of the atomic bomb follow-up program in Japan. He writes extremely well, with areas of his particular scientific interest described in great detail. He also describes events and the social implications in a manner that has broad, general appeal." —Stuart C. Finch, MD University of Medicine and Dentistry of New Jersey "A history of the Hiroshima/Nagasaki study is badly needed. I was very happy to hear that Jack Schull was working on such a project, and it is an understatement to say that I am anxious to see it published." —Seymour Jablon, PhD Bethesda, Maryland "Rarely in the history of a program will one have a nearly 50-year account from an eyewitness and major participant, beginning with the program's onset to the present. Jack's book offers the reader this extraordinary insight into the birth and development of the study of the A-bomb survivors. Moreover, he has served on all major national and international commissions dealing with radiation protection and risk assessment and he interweaves the Japanese studies into the radiation risk issues in a way that few, if any, other contemporary scientists can." —Seymour Abrahamson, PhD Radiation Effects Research Foundation On August 6 and 9, 1945, the only atomic bombs ever used in warfare were dropped on the Japanese cities of Hiroshima and Nagasaki. The destruction and death caused by those bombings presented the world with a vivid portrait of the dangers of the atomic age. However, the thousands of bomb survivors have given scientists a massive, firsthand perspective on the bioeffects of radioactivity. It is the study of these survivors that forms the foundation of the modern understanding of the immediate, long-term, and hereditary consequences of exposure to ionizing radiation. Effects of Atomic Radiation: A Half-Century of Studies from Hiroshima and Nagasaki is the definitive account of the methods, findings, and conclusions of the 50-year study on the survivors of the atomic bomb blasts. It is a truly monumental work, surveying a colossal body of data to offer a comprehensive, unified, and authoritative summary of not only the scientific study itself, but the personal, social, and political factors that have shaped the investigation from its inception. The book goes beyond the simple compilation of facts, giving the reader unique insight into this unprecedented research project and exploring the complex web of subjective perceptions and fears that color popular, national, and even scientific views of radiation exposure in moderate and extreme cases. Authored by Dr. William J. Schull, perhaps the single most influential scientist involved in the studies, this book conveys both his authority and sensitivity. Dr. Schull arrived in Japan in 1949 and was instrumental in the development of the Atomic Bomb Casualty Commission. Since then, he has been one of the driving forces behind the largest medical follow-up study ever undertaken. His years spent working directly with bomb survivors imbue his narrative with a compelling personal history, and his service on numerous national and international committees studying ionizing radiation give him a broad, authoritative perspective on the implications of the ABCC's work. Effects of Atomic Radiation: A Half-Century of Studies from Hiroshima and Nagasaki is first and foremost a scientific work, summarizing the core findings of the definitive study on radiation exposure; while throughout the book, the author provides personal accounts that illustrate the human dimensions of the bombings. In a world where nuclear power is increasing and exposure to radiation is a daily occurrence, this book is essential reading for all scientists associated with public, private, or governmental institutions that set standards of acceptability for exposure.

This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

Do persons exposed to radiation suffer genetic effects that threaten their yet-to-be-born children? Researchers are concluding that the genetic risks of radiation are less than previously thought. This finding is explored in this volume about the children of atomic bomb survivors in Hiroshima and Nagasakiâ€"the population that can provide the greatest insight into this critical issue. Assembled here for the first time are papers representing more than 40 years of research. These documents reveal key results related to radiation's effects on pregnancy termination, sex ratio, congenital defects, and early mortality of children. Edited by two of the principal architects of the studies, J. V. Neel and W. J. Schull, the volume also offers an important comparison with studies of the genetic effects of radiation on mice. The wealth of technical details will be immediately useful to geneticists and other specialists. Policymakers will be interested in the overall conclusions and discussion of future studies.

This book is the seventh in a series of titles from the National Research Council that addresses the effects of exposure to low dose LET (Linear Energy Transfer) ionizing radiation and human health. Updating information previously presented in the 1990 publication, Health Effects of Exposure to Low Levels of Ionizing Radiation: BEIR V, this book draws upon new data in both epidemiologic and experimental research. Ionizing radiation arises from both natural and man-made sources and at very high doses can produce damaging effects in human tissue that can be evident within days after exposure. However, it is the low-dose exposures that are the focus of this book. So-called “late” effects, such as cancer, are produced many years after the initial exposure. This book is among the first of its kind to include detailed risk estimates for cancer incidence in addition to cancer mortality. BEIR VII offers a full review of the available biological, biophysical, and epidemiological literature since the last BEIR report on the subject and develops the most up-to-date and comprehensive risk estimates for cancer and other health effects from exposure to low-level ionizing radiation.

Over the past several decades, public concern over exposure to ionizing radiation has increased. This concern has manifested itself in different ways depending on the perception of risk to different individuals and different groups and the circumstances of their exposure. One such group are those U.S. servicemen (the "Atomic Veterans" who participated in the atmospheric testing of nuclear weapons at the Nevada Test Site or in the Pacific Proving Grounds, who served with occupation forces in or near Hiroshima and Nagasaki, or who were prisoners of war in or near those cities at the time of, or shortly after, the atomic bombings. This book addresses the feasibility of conducting an epidemiologic study to determine if there is an increased risk of adverse reproductive outcomes in the spouses, children, and grandchildren of the Atomic Veterans.

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates