Double Blind follows three close friends and their circle through a year of extraordinary transformation. Set inLondon, Cap d'Antibes, Big Sur, and a rewilded corner of Sussex, this thrilling, ambitious novel is about the headlong pursuit of knowledge—for the purposes of pleasure, revelation, money, sanity, or survival—and the consequences of fleeing from what we know about others and ourselves. When Olivia meets a new lover just as she is welcoming her best friend, Lucy, back from New York, her dedicated academic life expands precipitously. Her connection to Francis, a committed naturalist living off the grid, is immediate and startling. Eager to involve Lucy in her joy, Olivia introduces the two—but Lucy has received shocking news of her own that binds the trio unusually close. Over the months that follow, Lucy’s boss, Hunter, Olivia’s psychoanalyst parents, and a young man named Sebastian are pulled into the friends’ orbit, and not one of them will emerge unchanged. Expansive, playful, and compassionate, Edward St. Aubyn's Double Blind investigates themes of inheritance, determinism, freedom, consciousness, and the stories we tell about ourselves. It is as compelling about ecology, psychoanalysis, genetics, and neuroscience as it is about love, fear, and courage. Most of all, it is a perfect expression of the interconnections it sets out to examine, and a moving evocation of an imagined world that is deeply intelligent, often tender, curious, and very much alive.

View our feature on Ann Aguirre’s Doubleblind.As a “Jumper” who navigates ships through grimspace, Sirantha Jax is used to kicking ass. So why is she suddenly chosen as an ambassador of peace?

A breakthrough account of how women can overcome the social binds that block their success. As Kathleen Hall Jamieson explores society's interlaced traps and restrictions, she draws on hundreds of interviews with women from all walks of life to show the ways they can cut through the restrictions.

“Bold, absorbing, insightful, and wise. . . . Read it: the truth is inside.”— Cheryl Strayed, author of Wild and Tiny Beautiful Things “A work of courage and ferocious honesty” (Diana Abu-Jaber), Double Bind could not come at a more urgent time. Even as major figures from Gloria Steinem to Beyoncé embrace the word “feminism,” the word “ambition” remains loaded with ambivalence. Many women see it as synonymous with strident or aggressive, yet most feel compelled to strive and achieve—the seeming contradiction leaving them in a perpetual double bind. Ayana Mathis, Molly Ringwald, Roxane Gay, and a constellation of “nimble thinkers . . . dismantle this maddening paradox” (O, The Oprah Magazine) with candor, wit, and rage. Women who have made landmark achievements in fields as diverse as law, dog sledding, and butchery weigh in, breaking the last feminist taboo once and for all. “Both intimate and scalable” (Atlantic.com), Double Bind finally seizes “ambition” from the roster of dirty words.

NATIONAL BESTSELLER • From the bestselling author of The Flight Attendant, here is a gripping psychological novel of obsession and consequence. When Laurel Estabrook is attacked while riding her bicycle through Vermont’s back roads, her life is forever changed. Formerly outgoing, Laurel withdraws into her photography, spending all her free time at a homeless shelter. There she meets Bobbie Crocker, a man with a history of mental illness and a box of photographs that he won’t let anyone see. When Bobbie dies, Laurel discovers a deeply hidden secret–a story that leads her far from her old life, and into a cat-and-mouse game with pursuers who claim they want to save her. In a tale that travels between the Roaring Twenties and the twenty-first century, between Jay Gatsby’s Long Island and rural New England, bestselling author Chris Bohjalian has written an extraordinary novel. Look for Chris Bohjalian's new novel, The Lioness!

The International Mystery Double Blind: The Icelandic Manuscript Murders is a wild ride through the cultural landscape of Iceland, from rural farmsteads to icy fjords to the high-tech world of DNA forensics. A young boy disappears in the chill of North Iceland. Twenty years later, a mysterious poem lands on the desk of his twin sister Brynja, a forensic geneticist, and rekindles her hopes that her brother might be alive. As Brynja unravels the clues, more poems arrive, each bearing dire consequences for those who receive them: the guard of the medieval manuscript of Icelandic sagas that may have the answer to her burning question, the prime minister's secretary, the local pastor. Is the poet out to stop Brynja from finding her brother and shut down her access to the DNA database? Or is the verse maker simply a psychopath copycat killer? Fighting the visual auras that have plagued her since childhood and now threaten everything she holds dear, Brynja must summon the strength to navigate the twisted labyrinth of the poet's mind and confront the dark secret buried in her family's past.

Planning a clinical study is much more than determining the basic study design. Who will you be studying? How do you plan to recruit your study subjects? How do you plan to retain them in the study? What data do you plan to collect? How will you obtain this data? How will you minimize bias? All these decisions must be consistent with the ethical considerations of studying people. This book teaches how to choose the best design for your question. Drawing on their many years working in clinical research, Nancy G. Berman and Robert A. Parker guide readers through the essential elements of study planning to help get them started. The authors offer numerous examples to illustrate the key decisions needed, describing what works, what does not work, and why. Written specifically for junior investigators beginning their research careers, this guide will also be useful to senior investigators needing to review specific topics.