Hybrid Frequentist/Bayesian Power and Bayesian Power in Planning Clinical Trials provides a practical introduction to unconditional approaches to planning randomised clinical trials, particularly aimed at drug development in the pharmaceutical industry. This book is aimed at providing guidance to practitioners in using average power, assurance and related concepts. This book brings together recent research and sets them in a consistent framework and provides a fresh insight into how such methods can be used. Features: A focus on normal theory linking average power, expected power, predictive power, assurance, conditional Bayesian power and Bayesian power. Extensions of the concepts to binomial, and time-to-event outcomes and non-inferiority trials An investigation into the upper bound on average power, assurance and Bayesian power based on the prior probability of a positive treatment effect Application of assurance to a series of trials in a development program and an introduction of the assurance of an individual trial conditional on the positive outcome of an earlier trial in the program, or to the successful outcome of an interim analysis Prior distribution of power and sample size Extension of the basic approach to proof-of-concept trials with dual success criteria Investigation of the connection between conditional and predictive power at an interim analysis and power and assurance Introduction of the idea of surety in sample sizing of clinical trials based on the width of the confidence intervals for the treatment effect, and an unconditional version.

"Philosophical Logic is a clear and concise critical survey of nonclassical logic, written by one of the world's leading authorities on the subject. After giving an overview of classical logic, John Burgess introduces five central branches of nonclassical logic (temporal, modal, conditional, relevantistic, and intuitionistic), focusing on the sometimes problematic relationship between formal apparatus and intuitive motivation. The book provides a thorough treatment of conditional logic, unifying probabilistic and model-theoretic approaches. It underscores the variety of approaches that have been taken to relevantistic and related logics, and stresses the problem of connecting formal systems to the motivating ideas behind intuitionistic mathematics. Requiring minimal background and arranged to make the more technical material optional, Philosophical Logic offers a choice between an overview and in-depth study, and it balances the philosophical and technical aspects of the subject."--Page 4 de la couverture.

Fully updated with all of the latest developments, this will give you a full understanding of the English Legal System.

Conditionals, Paradox, and Probability brings together fifteen original essays by experts in philosophy and linguistics. These specially written chapters draw on themes from the work of Dorothy Edgington, the first woman to hold a chair in philosophy at the University of Oxford. The contributors to this volume focus on the key topics to which Edgington has made many important contributions, including conditionals, vagueness, the paradox of knowability, and probability. Their insights will be of interest to philosophers, linguists, and psychologists working in philosophical logic, natural language semantics, and reasoning.

How insights from the social sciences, including social psychology and economics, can improve the design of online communities. Online communities are among the most popular destinations on the Internet, but not all online communities are equally successful. For every flourishing Facebook, there is a moribund Friendster—not to mention the scores of smaller social networking sites that never attracted enough members to be viable. This book offers lessons from theory and empirical research in the social sciences that can help improve the design of online communities. The authors draw on the literature in psychology, economics, and other social sciences, as well as their own research, translating general findings into useful design claims. They explain, for example, how to encourage information contributions based on the theory of public goods, and how to build members' commitment based on theories of interpersonal bond formation. For each design claim, they offer supporting evidence from theory, experiments, or observational studies.

Designed for students who may not have ready access to a law library, and for students on part-time and distance learning courses, the Sourcebook series offers a collection of material from a diversity of sources. The sources are annotated to set the materials in context and to explain their relevance and importance. This volume contains a representative selection of cases and statutes which cover such topics as the nature of law, sources of law, and the structure and jurisdiction of the civil and criminal courts. The legal profession and the interpretation of statutes are also discussed.