This text uses a case-study approach to present the fundamentals of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 32 cases, carefully selected to cover common diseases and important principles, are supplemented by clinical descriptions of each disease and a comprehensive discussion of the underlying pathophysiological mechanisms and associated enzymatic and chemical alterations in tissues and body fluids. The Second Edition differs from its predecessor in several respects. It features seven new chapters on diseases not covered before. The Biochemical Perspectives section of each chapter has been expanded to include pertinent information on the molecular biology of each disease. More chapters are written by authors from outside the U.S., and Dr. Glew has a new co-editor. The diseases covered include those caused by viruses (hepatitis B, HIV), microorganisms (diphtheria), environmental toxins (e.g. lead), cardiovascular abnormalities (myocardial infarction), genetic mutations (hereditary spherocytosis, Gaucher disease, sickle-cell anemia, chronic granulomatous disease), endocrine system disorders (hypertension, Cushing's syndrome), and nutritional deficiencies (rickets). Chapters follow a consistent format. A detailed case report describes the history, pertinent clinical laboratory data, histological findings, and physical characteristics. It is followed by a diagnosis section, which covers biochemical structures and the formulae of enzyme-catalyzed reactions, and describes the definitive method for confirming diagnosis. A discussion of biochemical and molecular perspectives provides a detailed account of the normal processes and reactions pertaining to the case, along with the mechanism of the disease. Therapeutic options are analyzed and the likely prognosis is outlined. Each chapter concludes with discussion questions and a brief bibliography listing informative reviews and key publications. This text is intended for medical schools where biochemistry is taught though the study of actual clinical cases, and will be useful to medical students, graduate students in the biomedical sciences, and practicing physians taking refresher courses.

This edition uses actual clinical cases to illustrate important principles of biochemistry and molecular biology in the context of human disease. The format of each chapter remains the same - case presentation, diagnosis, therapy and references.

The culmination of more than ten years of research by the authors, this book describes for the first time ever the scientific basis and clinical applications of medical biochemistry, a fundamental paradigm shift in medicine. This paradigm shift is so revolutionary that it has been called the Neustadt-Pieczenik Paradigm, which is the fusion and clinical applications of biochemistry, thermodynamics, physiology, fractal enzymology, nutritional medicine and laboratory testing to identify and correct the underlying causes of many diseases that are considered genetic in nature (eg, Phenylketonuria) and those that are not considered genetic (eg, mature onset asthma, depression, fatigue). In this new medicine, doctors must reject the failed, purely symptomatic treatments they learned in medical school and focus on learning and treating the underlying biochemical causes of disease. From the first documented clinical observations of biochemical individuality in the early 1900s to the development of sophisticated biochemical tests, the authors provide a detailed and stunning analysis of a new medical model to help millions and cure our ailing healthcare system. They uniquely contrast the conventional medical approach with the functional biochemical approach through extensive case studies on depression, arthritis, migraine headaches, seizures, rashes and more. This book is a must-read for physicians, medical students, nutritionists, and anyone looking to take charge of their health.

This text uses a case-study approach to present the fundamentals of biochemistry and molecular biology in the context of human disease to students who will be involved in patient care. The 32 cases, carefully selected to cover common diseases and important principles, are supplemented by clinical descriptions of each disease and a comprehensive discussion of the underlying pathophysiological mechanisms and associated enzymatic and chemical alterations in tissues and body fluids. The Second Edition differs from its predecessor in several respects. It features seven new chapters on diseases not covered before. The Biochemical Perspectives section of each chapter has been expanded to include pertinent information on the molecular biology of each disease. More chapters are written by authors from outside the U.S., and Dr. Glew has a new co-editor. The diseases covered include those caused by viruses (hepatitis B, HIV), microorganisms (diphtheria), environmental toxins (e.g. lead), cardiovascular abnormalities (myocardial infarction), genetic mutations (hereditary spherocytosis, Gaucher disease, sickle-cell anemia, chronic granulomatous disease), endocrine system disorders (hypertension, Cushing's syndrome), and nutritional deficiencies (rickets). Chapters follow a consistent format. A detailed case report describes the history, pertinent clinical laboratory data, histological findings, and physical characteristics. It is followed by a diagnosis section, which covers biochemical structures and the formulae of enzyme-catalyzed reactions, and describes the definitive method for confirming diagnosis. A discussion of molecular perspectives provides a detailed account of the normal processes and reactions pertaining to the case, along with the mechanism of the disease. The therapy is summarized and the likely prognosis is outlined. Each chapter concludes with discussion questions and a brief bibliography listing informative reviews and key publications. This text is intended for medical schools where biochemistry is taught though the study of actual clinical cases, and will be useful to medical students, graduate students in the biomedical sciences, and practicing physians taking refresher courses.

Expert biochemist N.V. Bhagavan’s new work condenses his successful Medical Biochemistry texts along with numerous case studies, to act as an extensive review and reference guide for both students and experts alike. The research-driven content includes four-color illustrations throughout to develop an understanding of the events and processes that are occurring at both the molecular and macrolecular levels of physiologic regulation, clinical effects, and interactions. Using thorough introductions, end of chapter reviews, fact-filled tables, and related multiple-choice questions, Bhagavan provides the reader with the most condensed yet detailed biochemistry overview available. More than a quick survey, this comprehensive text includes USMLE sample exams from Bhagavan himself, a previous coauthor. Clinical focus emphasizing relevant physiologic and pathophysiologic biochemical concepts Interactive multiple-choice questions to prep for USMLE exams Clinical case studies for understanding basic science, diagnosis, and treatment of human diseases Instructional overview figures, flowcharts, and tables to enhance understanding

"For over 30 years, this title sets the standard as a practical guide for physicians, nurses, pharmacists and other practitioners involved in all forms of clinical and public health research. It presents the epidemiologic concepts in a reader-friendly way and suggests common sense approaches to the challenging judgments involved in designing, funding and implementing a study. Translated in many languages over the years, it is a manual for clinical research in it various flavors: clinical trials, observational epidemiology, translated science, patient-oriented research. Epidemiologic- terms and principles, presented advanced conceptual material in a practical and reader friendly way and suggested common sense approaches to many judgments involved in designing a study"--