This book represents the results of 45 years of research on a wide range of topics, including atomic physics, single-molecule enzymology, whole-cell metabolism, physiology, pharmacology, linguistics, semiotics, and cosmology. It describes the first comprehensive molecular theory of the genotype-phenotype coupling based on two key theoretical concepts: (i) the conformon, the conformational wave packet in biopolymers carrying both the free energy and genetic information; and (ii) the intracellular dissipative structures, the chemical concentration waves inside the cell that serve as the immediate drivers of all cell functions. Conformons provide the driving forces for all molecular machines in the cell, and intracellular dissipative structures coordinate intra- and intercellular processes such as gene expression and cell-cell communications. One of the predictions made by the cell language theory (CLT) is that there are two forms of genetic information — the Watson–Crick genes transmitting information in time (identified with DNA), and the Prigoginian genes transmitting information in space (identified with RNA expression profiles). The former is analogous to sheet music or written language and the latter is akin to audio music or spoken language, both being coupled by conformons acting as the analog of the pianist. The new theory of DNA structure and function constructed on the basis of CLT can rationally account for most of the puzzling findings recently unearthed by the ENCODE (Encyclopedia of DNA Elements) project. The Cell Language Theory has important applications in biomedical sciences including drug discovery research and personalized medicine on the one hand and in the mind-body research and consciousness studies on the other. Contents: PrefaceAbout the AuthorAcknowledgementsIntroductionKey Terms and ConceptsThe BhopalatorCell LanguageMatrix Mathematics of GeneticsBiosemioticsApplications of the Cell Language Theory to Biomedical SciencesThe Universality of the Planckian Distribution EquationThe Universality of the Irreducible Triadic RelationThe Philosophical Implications of the Cell Language TheoryConclusionsReferencesAppendicesIndex Readership: Students, researchers and practitioners of the biomedical sciences and mind-body research and consciousness studies Keywords: Conformons;Cell Language Theory;Intracellular Dissipative Structures;Watson-Crick Gene;Prigoginian GeneReview:0

This book describes the first molecular theory of the genotype-phenotype coupling (or cell language) based on two key concepts: (i) the conformon, the packet of free energy and genetic information stored in biopolymers; and (ii) the intracellular dissipative structures, the concentration gradients in the cell that drive all cell functions. Conformons provide the driving forces for all molecular machines in the cell including ATP-dependent chromatin remodeling proteins, and dissipative structures coordinate cell-wide processes such as gene expression and cell cycle. One prediction of the new theory is that there are two forms of genetic information the WatsonCrick genes transmitting information in time (identified with DNA), and the Prigoginian genes transmitting information in space (identified with RNA expression profiles). The former is analogous to sheet music or written language, the latter is akin to audio music or spoken language, and conformons act as the pianist. The new theory of DNA structure and function can rationally account for most of the puzzling findings recently unearthed by the ENCODE (Encyclopedia of DNA Elements) project. The cell language theory described in this book, coupled with high-throughput experimental data and computational methods, is expected to facilitate the practical applications of cell biological knowledge to biomedical sciences, including diagnosis, therapeutics, and drug discovery.

This is the first attempt to delineate the synthetic field of the theoretical study of information, treating information as the basic phenomenon on the fundamental level of the world, encompassing nature, technology, individuals and society. The exploration of information is done within Info-computational approaches, to natural and social phenomena such as Bioinformatics, Information Physics, Informational Chemistry, Computational Physics, Cognitive and Social sciences, with special emphasis on interdisciplinary, crossdisciplinary and transdisciplinary knowledge.The book presents results of collaboration across research fields within info-computational and info-structural frameworks, in attempt to better theoretically and conceptually capture the phenomenon of information and its dynamics (such as computation and communication), as they appear on different levels of organization, on different scales and in different contexts.

In addition of proposing a model of language based on a bio-mathematical reduction within a synthesis between deduction, induction it suggests a much more important role of learning symmetry (especially iconicity) parallel to Universal Grammar. Without any theoretical megalomania, the model you will be discovering, reading and hopefully discussing hypothesizes two propositional principles with an important role of thermodynamic information : the shift from the bio-semiotic to the semiotic order along with the neural/dynamic mapping is embedded in the shift from thermodynamic laws without proposition (methodologically defined by hypothetic-probabilistic states of the ''internal observer'', Boltzmann-Bernoulli proposals and quantization) to biological and cultural consciousness (selection, combination, self-reference and symmetry etc etc)

This book includes the proceedings of the Second International Conference of Artificial Intelligence, Medical Engineering, Education (AIMEE2018), held in Moscow, Russia, on 6–8 October 2018. The conference covered advances in the development of artificial intelligence systems and their applications in various fields, from medicine and technology to education. The papers presented in the book discuss topics in mathematics and biomathematics; medical approaches; and technological and educational approaches. Given the rapid development of artificial intelligence systems, the book highlights the need for more intensive training for a growing number of specialists, particularly in medical engineering, to increase the effectiveness of medical diagnosis and treatment. The book is intended for specialists, students and other readers who would like to know where artificial intelligence systems can beneficially be applied in the future.

This book is the third component in the ROAL model; it suggests a relation between language and mathematical models of totality relying on verifiability and observability/objectivity models of the linguistic text. In addition of the biomathematical hypothesis, rules of observability and objectivity have been extended to both objective and non-objective models toward a manifolded dimension of the structure within a field dimension of consciousness in which dwells the paradigm of the text as a meta-observability domain for language and natural/individual languages.

The book is a collection of papers of experts in the fields of information and complexity. Information is a basic structure of the world, while complexity is a fundamental property of systems and processes. There are intrinsic relations between information and complexity. The research in information theory, the theory of complexity and their interrelations is very active. The book will expand knowledge on information, complexity and their relations representing the most recent and advanced studies and achievements in this area. The goal of the book is to present the topic from different perspectives — mathematical, informational, philosophical, methodological, etc.