Automation in Proteomics and Genomics

Automation in Proteomics and Genomics
Title Automation in Proteomics and Genomics PDF eBook
Author Gil Alterovitz
Publisher John Wiley & Sons
Total Pages 340
Release 2009-03-16
Genre Science
ISBN 9780470741177

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In the last decade DNA sequencing costs have decreased over a magnitude, largely because of increasing throughput by incremental advances in tools, technologies and process improvements. Further cost reductions in this and in related proteomics technologies are expected as a result of the development of new high-throughput techniques and the computational machinery needed to analyze data generated. Automation in Proteomics & Genomics: An Engineering Case-Based Approach describes the automation technology currently in the areas of analysis, design, and integration, as well as providing basic biology concepts behind proteomics and genomics. The book also discusses the current technological limitations that can be viewed as an emerging market rather than a research bottleneck. Topics covered include: molecular biology fundamentals: from ‘blueprint’ (DNA) to ‘task list’ (RNA) to ‘molecular machine’ (protein); proteomics methods and technologies; modelling protein networks and interactions analysis via automation: DNA sequencing; microarrays and other parallelization technologies; protein characterization and identification; protein interaction and gene regulatory networks design via automation: DNA synthesis; RNA by design; building protein libraries; synthetic networks integration: multiple modalities; computational and experimental methods; trends in automation for genomics and proteomics new enabling technologies and future applications Automation in Proteomics & Genomics: An Engineering Case-Based Approach is an essential guide to the current capabilities and challenges of high-throughput analysis of genes and proteins for bioinformaticians, engineers, chemists, and biologists interested in developing a cross-discipline problem-solving based approach to systems biology.

Proteome Research

Proteome Research
Title Proteome Research PDF eBook
Author Marc R. Wilkins
Publisher Springer Science & Business Media
Total Pages 270
Release 1997
Genre Medical
ISBN 9783540627531

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Introduction to the proteome (K. L. Williams, D. F. Hochstrasser). Two-dimensional electrophoresis: the state of the art and future directions (B. R. Herbert, J.-C. Sanchez, L. Bini). large-scale comparative protein modeling ( M. C. Peitsch, N. Guex); Clinical and biomedical applications of proteomics (D. F. Hochstrasser). Biological applications of proteomics (K. L. Williams, V. Pallini). Conclusions (D. F. Hochstrasser, L. Williams). Index.

Automation: Genomic and Functional Analyses

Automation: Genomic and Functional Analyses
Title Automation: Genomic and Functional Analyses PDF eBook
Author Alister G. Craig
Publisher Elsevier
Total Pages 296
Release 1999-02
Genre Science
ISBN 9780121948603

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Evaluation and functional analysis, to provide insight into this "new age" of research based on genomic and chemical screening. Key Features * Describes automated procedures used in microbiology and molecular biology * Includes developments in robotics and vision systems * Features automation in library picking, presentation and analysis * Discusses paralogous duplications in microbial genomes * Covers deciphering genomes through automated large-scale sequencing * Describes and stresses the need for functional analyses * Internationally acclaimed contributors, including Professor Leroy Hood.

Concepts and Techniques in Genomics and Proteomics

Concepts and Techniques in Genomics and Proteomics
Title Concepts and Techniques in Genomics and Proteomics PDF eBook
Author N Saraswathy
Publisher Elsevier
Total Pages 271
Release 2011-07-01
Genre Science
ISBN 1908818050

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Concepts and techniques in genomics and proteomics covers the important concepts of high-throughput modern techniques used in the genomics and proteomics field. Each technique is explained with its underlying concepts, and simple line diagrams and flow charts are included to aid understanding and memory. A summary of key points precedes each chapter within the book, followed by detailed description in the subsections. Each subsection concludes with suggested relevant original references. Provides definitions for key concepts Case studies are included to illustrate ideas Important points to remember are noted

Evolution of Translational Omics

Evolution of Translational Omics
Title Evolution of Translational Omics PDF eBook
Author Institute of Medicine
Publisher National Academies Press
Total Pages 354
Release 2012-09-13
Genre Science
ISBN 0309224187

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Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

Proteomics

Proteomics
Title Proteomics PDF eBook
Author Stephen R. Pennington
Publisher Garland Science
Total Pages 352
Release 2001
Genre Amino acid sequence
ISBN 9781859962961

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Proteomics is an emerging research area, and the book reviews genome projects in relation to the need for complementary proteomics programmes.

Genomics and Proteomics for Clinical Discovery and Development

Genomics and Proteomics for Clinical Discovery and Development
Title Genomics and Proteomics for Clinical Discovery and Development PDF eBook
Author György Marko-Varga
Publisher Springer
Total Pages 285
Release 2014-08-26
Genre Science
ISBN 940179202X

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The book is intended to be a resource for students as well as scientists in education and for the general public to learn about proteomics and genomics. Chromosomes form the basis for our genetic heritage and are the code for protein synthesis. The Human Genome Map came out in 2002, and the Proteome Sequence Map is under currently being created by a global consortia initiative. Proteome and genome building blocks already form the basis of scientific research areas as well as large parts of the pharmaceutical and biomedical industry. The book initiative will provide the background to and our current understanding of these gene and protein areas, as well as describe how cutting-edge science is using these resources to develop new medicines and new diagnostics for patient care and treatment. The book will be useful for undergraduate students as well as university students and researchers who need a good understanding of genomics and proteomics within the clinical field. The book will also be targeted at a broad public as well as readers not specialized within this field. Dr. Marko-Varga is the head of the Head of Div. Clinical Protein Science & Imaging at the Biomedical Center, Dept. of Measurement Technology and Industrial Electrical Engineering, Lund University, and Professor at the 1st Department of Surgery, Tokyo Medical University, Tokyo, Japan.