Recent advances in computational algorithms, along with the advent of whole slide imaging as a platform for embedding artificial intelligence (AI), are transforming pattern recognition and image interpretation for diagnosis and prognosis. Yet most pathologists have just a passing knowledge of data mining, machine learning, and AI, and little exposure to the vast potential of these powerful new tools for medicine in general and pathology in particular. In Artificial Intelligence and Deep Learning in Pathology, Dr. Stanley Cohen covers the nuts and bolts of all aspects of machine learning, up to and including AI, bringing familiarity and understanding to pathologists at all levels of experience. Focuses heavily on applications in medicine, especially pathology, making unfamiliar material accessible and avoiding complex mathematics whenever possible. Covers digital pathology as a platform for primary diagnosis and augmentation via deep learning, whole slide imaging for 2D and 3D analysis, and general principles of image analysis and deep learning. Discusses and explains recent accomplishments such as algorithms used to diagnose skin cancer from photographs, AI-based platforms developed to identify lesions of the retina, using computer vision to interpret electrocardiograms, identifying mitoses in cancer using learning algorithms vs. signal processing algorithms, and many more.

Data driven Artificial Intelligence (AI) and Machine Learning (ML) in digital pathology, radiology, and dermatology is very promising. In specific cases, for example, Deep Learning (DL), even exceeding human performance. However, in the context of medicine it is important for a human expert to verify the outcome. Consequently, there is a need for transparency and re-traceability of state-of-the-art solutions to make them usable for ethical responsible medical decision support. Moreover, big data is required for training, covering a wide spectrum of a variety of human diseases in different organ systems. These data sets must meet top-quality and regulatory criteria and must be well annotated for ML at patient-, sample-, and image-level. Here biobanks play a central and future role in providing large collections of high-quality, well-annotated samples and data. The main challenges are finding biobanks containing ‘‘fit-for-purpose’’ samples, providing quality related meta-data, gaining access to standardized medical data and annotations, and mass scanning of whole slides including efficient data management solutions.

Artificial Intelligence Applications in Human Pathology deals with the latest topics in biomedical research and clinical cancer diagnostics. With chapters provided by true international experts in the field, this book gives real examples of the implementation of AI and machine learning in human pathology.Advances in machine learning and AI in general have propelled computational and general pathology research. Today, computer systems approach the diagnostic levels achieved by humans for certain well-defined tasks in pathology. At the same time, pathologists are faced with an increased workload both quantitatively (numbers of cases) and qualitatively (the amount of work per case, with increasing treatment options and the type of data delivered by pathologists also expected to become more fine-grained). AI will support and leverage mathematical tools and implement data-driven methods as a center for data interpretation in modern tissue diagnosis and pathology. Digital or computational pathology will also foster the training of future computational pathologists, those with both pathology and non-pathology backgrounds, who will eventually decide that AI-based pathology will serve as an indispensable hub for data-related research in a global health care system.Some of the specific topics explored within include an introduction to DL as applied to Pathology, Standardized Tissue Sampling for Automated Analysis, integrating Computational Pathology into Histopathology workflows. Readers will also find examples of specific techniques applied to specific diseases that will aid their research and treatments including but not limited to; Tissue Cartography for Colorectal Cancer, Ki-67 Measurements in Breast Cancer, and Light-Sheet Microscopy as applied to Virtual Histology.The key role for pathologists in tissue diagnostics will prevail and even expand through interdisciplinary work and the intuitive use of an advanced and interoperating (AI-supported) pathology workflow delivering novel and complex features that will serve the understanding of individual diseases and of course the patient.

The definitive, complete reference of digital pathology! An extraordinarily comprehensive and complete book for individuals with anything from minimal knowledge to deep, accomplished experience in digital pathology. Easy to read and plainly written, Digital Pathology examines the history and technological evolution of digital pathology, from the birth of scanning technology and telepathology to three-dimensional imaging on large multi-touch displays and computer aided diagnosis. A must-have book for anyone wishing to learn more about and work in this exciting and critical information environment including pathologists, laboratory professionals, students and any other medical practitioners with a particular interest in the history and future of digital pathology. It can also be a useful reference for anyone, medical or non-medical, who have an interest in learning more about the field. Digital pathology is truly a game changer, and this book is a crucial tool for anyone wishing to know more. Subjects discussed in depth include: Static digital imaging; basics and clinical use. Digital imaging processes. Telepathology. While slide imaging. Clinical applications of whole slide imaging. Digital pathology for educational, quality improvement, research and other settings. Forensic digital imaging.

A Science Friday pick for book of the year, 2019 One of America's top doctors reveals how AI will empower physicians and revolutionize patient care Medicine has become inhuman, to disastrous effect. The doctor-patient relationship--the heart of medicine--is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality. By freeing physicians from the tasks that interfere with human connection, AI will create space for the real healing that takes place between a doctor who can listen and a patient who needs to be heard. Innovative, provocative, and hopeful, Deep Medicine shows us how the awesome power of AI can make medicine better, for all the humans involved.

Winner of the "Outstanding Academic Title" recognition by Choice for the 2020 OAT Awards. The Choice OAT Award represents the highest caliber of scholarly titles that have been reviewed by Choice and conveys the extraordinary recognition of the academic community. The book discusses varied topics pertaining to advanced or up-to-date techniques in medical imaging using artificial intelligence (AI), image recognition (IR) and machine learning (ML) algorithms/techniques. Further, coverage includes analysis of chest radiographs (chest x-rays) via stacked generalization models, TB type detection using slice separation approach, brain tumor image segmentation via deep learning, mammogram mass separation, epileptic seizures, breast ultrasound images, knee joint x-ray images, bone fracture detection and labeling, and diabetic retinopathy. It also reviews 3D imaging in biomedical applications and pathological medical imaging.

This book constitutes the refereed proceedings of the 15th European Congress on Digital Pathology, ECDP 2019, held in Warwick, UK in April 2019. The 21 full papers presented in this volume were carefully reviewed and selected from 30 submissions. The congress theme will be Accelerating Clinical Deployment, with a focus on computational pathology and leveraging the power of big data and artificial intelligence to bridge the gaps between research, development, and clinical uptake.