Adult Onset

Adult Onset
Title Adult Onset PDF eBook
Author Ann-Marie MacDonald
Publisher Knopf Canada
Total Pages 374
Release 2014-09-30
Genre Fiction
ISBN 0345808290

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From the acclaimed, bestselling author of 2 beloved classics, Adult Onset is a powerful drama about motherhood, the dark undercurrents that break and hold families together, and the power and pressures of love. Mary Rose MacKinnon--nicknamed MR or "Mister"--is a successful YA author who has made enough from her writing to semi-retire in her early 40s. She lives in a comfortable Toronto neighbourhood with her partner, Hilary, a busy theatre director, and their 2 young children, Matthew and Maggie, trying valiantly and often hilariously to balance her creative pursuits with domestic demands, and the various challenges that (mostly) solo parenting presents. As a child, Mary Rose suffered from an illness, long since cured and "filed separately" in her mind. But as her frustrations mount, she experiences a flare-up of forgotten symptoms which compel her to rethink her memories of her own childhood and her relationship with her parents. With her world threatening to unravel, the spectre of domestic violence raises its head with dangerous implications for her life and that of her own children.

Adult Onset

Adult Onset
Title Adult Onset PDF eBook
Author Ann-Marie MacDonald
Publisher Hachette UK
Total Pages 361
Release 2014-09-30
Genre Fiction
ISBN 1473610125

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'Ann-Marie MacDonald captures the dark hilarity of parenthood like nobody else. I gulped down Adult Onset in a single day.' Emma Donoghue, author of Room A NUMBER ONE BESTSELLER IN CANADA Mary Rose McKinnon has two children with her partner Hilary and a fractured relationship with her mother Dolly; she also has issues with anger management and lives in fear of hurting the children and these feelings seem somehow rooted in a part of her childhood she has trouble remembering. Is Dolly - the kind of big personality who makes all Mary Rose's friends, and even waiters in coffee shops, exclaim 'I love your Mum!' - really harbouring a dark secret about what caused Mary Rose's childhood injuries, and is Mary Rose doomed to follow the same path with her own children? ADULT ONSET is a heartbreaking, hilarious, hugely satisfying novel about family ties and the joy and agony of parenthood. Ann-Marie MacDonald gets under the reader's skin and gives voice to the feelings we have all experienced but may never have examined.

Wounded By Reality

Wounded By Reality
Title Wounded By Reality PDF eBook
Author Ghislaine Boulanger
Publisher Routledge
Total Pages 197
Release 2011-02-25
Genre Psychology
ISBN 113687304X

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The culmination of three decades of studying and treating survivors of adult onset trauma, Wounded by Reality is the first systematic attempt to differentiate adult onset trauma from childhood trauma, with which it is frequently confused. When catastrophic events overtake adult lives, they often scar the psyche in ways that psychodynamically oriented clinicians struggle to understand. For Ghislaine Boulanger, the enormous challenge of working with these patients is unsurprising. Survivors of major catastrophe, whether a natural disaster, a life-threatening assault, a serious accident, or an act of terrorism, experience a near-fatal disruption of fundamental aspects of self experience. The sense of agency, of affectivity, of bodily integrity, the capacity for self-reflection, the sense of time, and the ability to relate to others - all are called into question.

Growth Hormone Deficiency in Adults

Growth Hormone Deficiency in Adults
Title Growth Hormone Deficiency in Adults PDF eBook
Author Jens O. L. Jørgensen
Publisher Karger Medical and Scientific Publishers
Total Pages 241
Release 2005-01-01
Genre Science
ISBN 3805579926

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It has been known for over 40 years that GH-deficient-children benefit from replacement with the hormone. But GH, essential for longitudinal growth, also plays a role after completion of final height. With the introduction of biosynthetic human GH 20 years ago, the use of GH was no longer restricted to severe growth retardation in hypopituitary children. This book will take the reader behind the myths of GH and into the real world of clinical endocrinology. The contributions stem from recognized clinicians and scientists who have been working in the field for decades. The contents encompass traditional end points of GH therapy such as body composition, bone biology and physical performance. Attention is also devoted to diagnostic aspects and side effects. Additional features range from clinical epidemiology to quality of life, and novel areas such as the impact of traumatic brain injury on pituitary function are also covered. The present volume of Frontiers of Hormone Research is essential reading for health care professionals interested in clinical endocrinology and GH.

The Way the Crow Flies

The Way the Crow Flies
Title The Way the Crow Flies PDF eBook
Author Ann-Marie MacDonald
Publisher Harper Collins
Total Pages 848
Release 2009-10-13
Genre Fiction
ISBN 0061840998

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“One of the finest novels I’ve read . . . .a fiercely intelligent look at childhood, marriage, families, the 1960s, the Cold War and the fear and isolation that are part of the human condition…. it is not only beautifully written…. it is equally beautiful in its conception, its compassion, its wisdom, even in its anger and pain. Don’t miss it.” — Patrick Anderson, Washington Post Book World The optimism of the early sixties, infused with the excitement of the space race and the menace of the Cold War, is filtered through the rich imagination of high-spirited, eight-year-old Madeleine, who welcomes her family's posting to a quiet Air Force base near the Canadian border. Secure in the love of her beautiful mother, she is unaware that her father, Jack, is caught up in a web of secrets. When a local murder intersects with global forces, Jack must decide where his loyalties lie, and Madeleine will be forced to learn a lesson about the ambiguity of human morality -- one she will only begin to understand when she carries her quest for the truth, and the killer, into adulthood twenty years later.

Textbook of Autoinflammation

Textbook of Autoinflammation
Title Textbook of Autoinflammation PDF eBook
Author Philip J. Hashkes
Publisher Springer
Total Pages 820
Release 2019-02-13
Genre Medical
ISBN 3319986058

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This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.

Periodic and Non-Periodic Fevers

Periodic and Non-Periodic Fevers
Title Periodic and Non-Periodic Fevers PDF eBook
Author Rolando Cimaz
Publisher Springer Nature
Total Pages 283
Release 2019-10-29
Genre Medical
ISBN 3030190552

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This book, written by very well-known opinion leaders in the field, covers all aspects of periodic and non –periodic fevers, and related disorders. The expression refers to several different auto-inflammatory diseases, showing similar symptoms–the primary symptom being a recurrent fever for an infectious cause cannot be found. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications in both pediatric and adult patients. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. Autoinflammatory diseases are hereditary disorders that are caused by single-gene defects in innate immune regulatory pathways and are characterized by a clinical and biological inflammatory syndrome in which there is limited, if any, evidence of autoimmunity. Periodic and Non-Periodic Fevers will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these disease.